Endocrine Abstracts

Tumor angiogenesis is believed to result from an imbalance of pro- and anti-angiogenic factors. Angiogenesis is an important component in the development of thyroid goitre. Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) represents a family of specific endothelial cell mitogens involved in normal angiogenesis and in tumor development. Consequently, a panel of anti-angiogenic factors was addressed in a representative sample of VEGF receptor-2 (VEGFR-...

Objective: The aim of this study was to evaluate the influence of subclinical and overt hyperthyroidism on the chosen markers of endothelial function.Material and methods: The groups studied consisted of 97 hyperthyroid subjects (51 with subclinical and 46 with overt hyperthyroidism) and 39 healthy controls matched for age, gender and body mass index. The following parameters were measured: TSH, FT3, FT4 (by MEIA), VCAM-1 (vascular cell adhesion molecule...

The aim of our study was to evaluate the short term efficacy of radioiodine therapy (RIT) to reduce thyroid volume with minimal risk of hypothyroidism in patients with non-toxic nodular goitre. Material and Methods: We treated 120 patients, aged 20–76 years; (88%) of the studied groups were female and (12%) male. Initial 24 h RAIU was ranged between 22–44% and effective half-life was more than 3 days. Thyroid volume ranged between 42–170 ml. Malignant changes we...

Oxidative stress plays an important role in hyperthyroidism-induced tissue damage. We aimed to determine whether radioiodine therapy has benefit effect on the oxidant and antioxidant status in patients with Graves’ Disease.Material and methods: We studied 30 patients with Graves’ disease, aged 18–48 years. 12 normal adult volunteers were studied as control group. All the patients were treated unsuccessfully by antithyroid drugs. The effect...

Before the introduction of mandatory salt iodination in 1997 the North-Eastern Region of Poland was known to be a moderate iodine deficiency area. It was also exposed to ionizing radiation after the Chernobyl accident in 1986. The aim of the present study was to evaluate the descriptive epidemiological features of incident thyroid cancers diagnosed among the residents of this area between 1996 and 2007. The Regional Cancer Surveillance Program was used to collect data on 834 n...

Gestational diabetes mellitus (GDM) identifies a population of women at high risk of subsequent type 2 diabetes mellitus, representing an early stage in the natural history of the disease. Systemic inflammation is associated with the development of type 2 diabetes but the data concerning pro- and anti-inflammatory cytokines in patients with GDM are limited. The aim of our study was to investigate serum concentrations of interleukin-8 (IL-8), IL-18 and IL-10 in pregnant women w...

Aim: The aim of our study was to evaluate the short-term (5 years) effect of radioiodine therapy (RAIT) on the achievement of euthyroidism, and prevention evolvement to overt hyperthyroidism.Material and methods: We treated 150 patients, aged 30–70 years; 54 patients with multinodular goitre (MNG), and 96 patients with autonomous nodule (ATN). Malignant changes were excluded in all nodules by fine needle aspiration biopsy. All the patients had serum...

Oxidative stress plays an important role in hyperthyroidism induced – tissue damage.We aimed to determine whether radioiodine therapy (RIT) has benefit effect on the oxidant and antioxidant status in subclinical hyperthyroidism.Material and methods: We studied 40 patients with untreated subclinical hyperthyroidism, (33 female, 7 male), aged 23–78 years; 14 patients with multinodular goitre, and 25 patients with solitary a...

The aim of our study was to assess the effectiveness of radioiodine therapy (RIT) on the achievement of euthyroidism and reduction of thyroid volume, in patients with toxic nodular goitre (TNG).Material and methods: During the last 7 years, we treated 3800 patients with TNG, aged 30-70 years; 82% female and 18% male; 2200 patients with multinodular goitre (MNG) and 1600 with autonomous toxic nodule (ATN); thyroid volume ranged between 16 and 130 ml (30% ...

The aim of our study was to assess the influence of radioiodine (131I) therapy on the achievement of euthyroidism, prevention of adverse effects on the cardiovascular and skeletal systems and prevent evolvement to overt hyperthyroidism.Material and methods: We treated 630 patients, aged 30–70 years; 85% of them were female and 15% male; 220 patient with multinodular goitre (MNG), and 310 patient with autonomous nodule (ATN). Some of the p...